maSigPro: a method to identify significantly differential expression profiles in time-course microarray experiments

maSigPro: a Method to Identify Significantly Differential Expression Profiles in Time-Course Microarray Experiments

MOTIVATION Multi-series time-course microarray experiments are useful approaches for exploring biological processes. In this type of experiments, the researcher is frequently interested in studying gene expression changes along time and in evaluating trend differences between the various experimental groups. The large amount of data, multiplicity of experimental conditions and the dynamic natur...

Significance analysis of time course microarray experiments.

Characterizing the genome-wide dynamic regulation of gene expression is important and will be of much interest in the future. However, there is currently no established method for identifying differentially expressed genes in a time course study. Here we propose a significance method for analyzing time course microarray studies that can be applied to the typical types of comparisons and samplin...

Mycoplasma infection significantly alters microarray gene expression profiles.

DynOmics to identify delays and co-expression patterns across time course experiments

Dynamic changes in biological systems can be captured by measuring molecular expression from different levels (e.g., genes and proteins) across time. Integration of such data aims to identify molecules that show similar expression changes over time; such molecules may be co-regulated and thus involved in similar biological processes. Combining data sources presents a systematic approach to stud...

Discovering gene expression patterns in time course microarray experiments by ANOVA-SCA

MOTIVATION Designed microarray experiments are used to investigate the effects that controlled experimental factors have on gene expression and learn about the transcriptional responses associated with external variables. In these datasets, signals of interest coexist with varying sources of unwanted noise in a framework of (co)relation among the measured variables and with the different levels...